Lead Guest Editor
Phuc Van Pham, University of Science, Ho Chi Minh City, Vietnam email@example.com
Wasim S. Khan, Royal National Orthopaedic Hospital, London, UK firstname.lastname@example.org
Gero Hütter, Cellex Gesellscha für Zellgewinnung mbH, Dresden, Germany email@example.com
Friday, 22 April 2016
First Round of Reviews
Friday, 15 July 2016
Friday, 9 September 2016
There has been a signi cant interest in clinical applications of stem cells in recent years, and the safety of these therapies is of particular interest to both scientists and physicians. ere is interest in the potential risk of tumorigenesis in vivo a er stem cell transplantation with several hypotheses suggesting that tumorigenesis and some side e ects may be related to stem cell characteristics and modi cations in stem cells during the in vitro long-term expansion. Some studies have shown that the use of stem cells without in vitro expansion was safe in both preclinical and clinical applications.
Although there was some evidence of genetic alterations of expanded stem cells, in vitro expanded stem cells have been used in Phase II and Phase III clinical trials for di erent diseases. All trials showed that expanded stem cell transplantation was safe and had bene cial results on disease improvement.
In this special issue, we invite researchers to submit original research and review articles to contribute to the topic safety of stem cell transplantation.
Potential topics include, but are not limited to:
Tumorigenesis or side e ects and complications of stem cell transplantation Long-term safety of stem cell transplantation
Safety of nonexpanded stem cells therapy
Safety of ex vivo expanded stem cells therapy
Safety of autologous stem cell transplantation
Safety of allogenic stem cells for stem cell transplantation
Preclinical safety assessment of stem cell transplantation
Safety of in vitro assessment of stem cell transformation
GMP aspects in the eld of stem cell transplantation
Safety of pluripotent stem cells or embryonic stem cell transplantation Safety of adult stem cell transplantation
In vitro stem cell expansion for clinical transplantation
Manipulated stem cells (gene therapy)
Authors can submit their manuscripts via the Manuscript Tracking System at http://mts.hindawi.com/submit/journals/sci/ssct/.