Lead Guest Editor
Andrea Ballini, University of Bari Aldo Moro, Bari, Italy email@example.com
Marco Tatullo, Tecnologica Research Institute, Crotone, Italy firstname.lastname@example.org
Antonio Boccaccio, Politecnico di Bari, Bari, Italy
Phuc Van Pham, Vietnam National University, Ho Chi Minh City, Vietnam email@example.com
Rajiv Saini, Pravara Institute of Medical Sciences, Rahata, India firstname.lastname@example.org
Friday, 12 May 2017
First Round of Reviews
Friday, 4 August 2017
Friday, 29 September 2017
Regenerative medicine is an innovative eld of medicine that is also developing in dental and maxillofacial sciences. Dental-derived mesenchymal stem cells (D- dMSC) are an intriguing milestone of the regenerative medicine, with regard to their potential of di erentiating into osteogenic, adipogenic, and chondrogenic lineages. Healing occurs when the regenerated tissue has been integrated into the neighboring host tissue and the di erentiation process has been thoroughly performed. Complete healing might be achieved by establishing novel strategies of using sca olds in combination with pretreated and/or untreated mesenchymal stem cells in the presence of selective di erentiation factors.
In regenerative medicine, the stem cells secretome, in particular for mesenchymal stem/stromal cells, is increasingly considered as a main promoter of the bene cial e ects of stem cell transplantation. Bioengineered/biomimetic sca olds, engineered peptide, and protein materials provide the advantages of a biological matrix with the control of a synthetic polymer. ey could be considered a merger of the two, retaining the bioactivity of harvested protein materials, like collagen and brin, with the control and tunability of synthetic, chemically de ned materials, such as poly(ethylene glycol) (PEG) and poly(lactic-co-glycolic acid) (PLGA).
Following this approach, peptide-loaded tHA (tHA/pep) particles blended with scaf- folds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. However, much still needs to be elucidated, in order to be able to create e cient and safe bioarti cial substitutes for clinical use.
In this special issue, we invite worldwide researchers as well as the clinicians con dent in the translational regenerative medicine to submit their most interesting overviews, reviews, and original papers describing the good, the bad, and the ugly of D-dMSC interactions with sca olds and biomaterials, including investigation on the potential of mesenchymal stem cell secretome and its manipulation, for the development of regenerative medicine approaches.
Potential topics include but are not limited to the following:
Mesenchymal stem cells in translational research and therapeutic strategies towards tissue regeneration and wound healing
Growth factors e ects on mesenchymal stem cells
Mesenchymal stem cells delivery/routes
e importance of three-dimensional cell culture models (e.g., hydrogels) for understanding cell-ECM interactions in most tissue types
Use of stem cells secretome or its components in immunomodulatory strategies, to promote tissue repair/regeneration
Extracellular matrix and bioactive molecules
Stem cells based on biosca old tissue models
Impact of biomaterials structure and composition on stem cell behavior and di erentiation
Computational models investigating the mechanobiology of D-dMSC and their interactions with sca olds for tissue engineering
Clinical research on application of D-dMSC and their cross talk with engineered peptide and protein materials, including bioengineered/biomimetic sca olds, secre- tome, feasibility, and “proof-of-concept” studies, new methodological paradigms that challenge current thinking in clinical research, and development of clinical- grade D-dMSC in matrix remodeling under good manufacturing practice proto- cols/conditions as an essential step towards clinical application and other similar studies are warmly welcome topics.
Authors can submit their manuscripts through the Manuscript Tracking System at http://mts.hindawi.com/submit/journals/sci/ddsc/.