This book focuses on the identification of basic mechanisms that are associated with aging, e.g. in the
bone and the skin, as well as tools and techniques applied in regenerative medicine. Aging is a process
guided by a large number of signaling molecules and gene regulatory factors acting to establish specific gene expression patterns. The mechanisms that lead to impaired healing with increasing age remain
largely unknown. Therefore, manipulation of key factors of regenerative processes within regulatory
networks should help to improve regeneration in a therapeutic setting.
Accordingly, an understanding of molecular and signaling mechanisms underlying the aging process
is likely to lead to novel approaches of preventing and treating age-related diseases. A combination of
high throughput approaches and advanced computational techniques to dissect the molecular mechanisms
of stem cell fate and cellular reprogramming are applied in regenerative medicine.
The aim of this publication is focused on the translation of basic science discoveries into regenerative
therapies, as well as the application of clinical tools in aging and tissue regeneration.